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1

Use of the Analgesic, Anti-inflammatory and Neuroprotectant Supplement Palmitoylethanolamide in the Tarsal Tunnel Syndrome

Hesselink, Jan M Keppel

Journal:

Clinical Research on Foot & Ankle

Year:

2015

File:

PDF, 239 KB

2015

2

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series

Keppel Hesselink, Jan, Hekker,

Journal:

Journal of Pain Research

Year:

2012

Language:

english

File:

PDF, 220 KB

english, 2012

3

St John's Wort and its Active Principles in Dipression and Anxiety. W. E. Müller. Birkhausen Verlag: Basel, Switzerland. 2005. ISBN 3-7643-6160-3. Pages 188.

Jan M. Keppel Hesselink

Journal:

Human Psychopharmacology: Clinical and Experimental

Year:

2005

Language:

english

File:

PDF, 29 KB

english, 2005

4

Topical Amitriptyline in Post-Traumatic Neuropathic Pain

Remko Liebregts, David J. Kopsky, Jan M. Keppel Hesselink

Journal:

Journal of Pain and Symptom Management

Year:

2011

Language:

english

File:

PDF, 40 KB

english, 2011

5

Intractable Neuropathic Pain in Spinal Intramedullary Cavernoma Treated Successfully with a Novel Combination Cream

DAVID JOS KOPSKY, GERRIT JOHAN AMELINK, JAN MARIUS KEPPEL HESSELINK

Journal:

Year:

2012

Language:

english

File:

PDF, 213 KB

english, 2012

6

High Doses of Topical Amitriptyline in Neuropathic Pain: Two Cases and Literature Review

David J. Kopsky, Jan M. Keppel Hesselink

Journal:

Year:

2012

Language:

english

File:

PDF, 61 KB

english, 2012

7

Palmitoylethanolamide (PEA)—‘Promiscuous’ anti-inflammatory and analgesic molecule at the interface between nutrition and pharma

Keppel Hesselink, Jan M., Kopsky, David J., Witkamp, Renger F.

Journal:

PharmaNutrition

Year:

2014

Language:

english

File:

PDF, 521 KB

english, 2014

8

Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action

Keppel Hesselink, Jan M., Kopsky, David J.

Journal:

Journal of Neurology

Year:

2017

Language:

english

File:

PDF, 522 KB

english, 2017

9

Phenytoin: neuroprotection or neurotoxicity?

Keppel Hesselink, Jan M., Kopsky, David J.

Journal:

Neurological Sciences

Year:

2017

Language:

english

File:

PDF, 255 KB

english, 2017

10

Effectiveness of ipsapirone, a 5-HT-1A partial agonist, in major depressive disorder: support for the role of 5-HT-1A receptors in the mechanism of action of serotonergic antidepressants

Stahl, Stephen M., Kaiser, Lee, Roeschen, Julie, Keppel Hesselink, Jan M., Orazem, John

Journal:

The International Journal of Neuropsychopharmacology

Year:

1998

Language:

english

File:

PDF, 249 KB

english, 1998

11

Phenytoin Cream for the Treatment for Neuropathic Pain: Case Series

Kopsky, David, Keppel Hesselink, Jan

Journal:

Pharmaceuticals

Year:

2018

Language:

english

File:

PDF, 529 KB

english, 2018

12

Phenytoin and carbamazepine in trigeminal neuralgia: marketing-based versus evidence-based treatment

Keppel Hesselink, Jan, Schatman, Michael

Journal:

Journal of Pain Research

Year:

2017

Language:

english

File:

PDF, 123 KB

english, 2017

13

Evolution in pharmacologic thinking around the natural analgesic palmitoylethanolamide: from nonspecific resistance to PPAR-α agonist and effective nutraceutical

Keppel Hesselink, Jan

Journal:

Journal of Pain Research

Year:

2013

Language:

english

File:

PDF, 367 KB

english, 2013

14

Single-Blind Placebo-Controlled Response Test with Phenytoin 10% Cream in Neuropathic Pain Patients

Kopsky, David, Keppel Hesselink, Jan

Journal:

Pharmaceuticals

Year:

2018

Language:

english

File:

PDF, 202 KB

english, 2018

15

Palmitoylethanolamide: A Useful Adjunct in Chemotherapy Providing Analgesia and Neuroprotection

Hesselink, Jan M. Keppel

Journal:

Chemotherapy Open access

Year:

2013

Language:

english

File:

PDF, 589 KB

english, 2013

16

Ipsapirone in the treatment of bulimia nervosa: An open pilot study

Dr. Christian Geretsegger, Karoline V. Greimel, Llona S. Roed, Jan M. Keppel Hesselink

Journal:

Journal of Eating Disorders

Year:

1995

Language:

english

File:

PDF, 326 KB

english, 1995

17

Concise guide to the cytochrome P450 system. Drug interaction principles for medical practice. Kelly L. Cozza and Scott C. Armstrong. American Psychiatric Publishing, Washington DC, 2001. Pages: 272. ISBN: 1-58562-000-9. Paperback. Price: £25.50

Jan M. Keppel Hesselink

Journal:

Human Psychopharmacology: Clinical and Experimental

Year:

2002

Language:

english

File:

PDF, 35 KB

english, 2002

18

Letter to editor

Jan M. Keppel Hesselink

Journal:

Human Psychopharmacology: Clinical and Experimental

Year:

1992

Language:

english

File:

PDF, 183 KB

english, 1992

19

Nerve Regeneration in Neuropathic Pain

David J. Kopsky, Jan M. Keppel Hesselink

Journal:

Year:

2010

Language:

english

File:

PDF, 100 KB

english, 2010

20

Depression in the course of treatment of generalized anxiety disorder with lorazepam, ipsapirone, and placebo: Results from a multicenter trial

John J. Sramek, Neal R. Cutler, Jerome F. Costa, Jan M. Keppel Hesselink, Randall D. Seifert, Evelyn Graham

Journal:

Year:

1993

Language:

english

File:

PDF, 497 KB

english, 1993

21

De toekomstige medicamenteuze behandeling van de ziekte van Alzheimer: van symptomatische naar causale therapie

Jan Marius, Keppel Hesselink

Journal:

Year:

1998

Language:

dutch

File:

PDF, 160 KB

dutch, 1998

22

A New Combination Cream for the Treatment of Severe Neuropathic Pain

David J. Kopsky, Jan M. Keppel Hesselink

Journal:

Journal of Pain and Symptom Management

Year:

2010

Language:

english

File:

PDF, 42 KB

english, 2010

23

Effectiveness of the association micronized N-palmitoylethanolamine (PEA)-transpolydatin in the treatment of chronic pelvic pain

Jan M. Keppel Hesselink

Journal:

European Journal of Obstetrics & Gynecology and Reproductive Biology

Year:

2011

Language:

english

File:

PDF, 99 KB

english, 2011

24

Intractable neuropathic pain due to ulnar nerve entrapment treated with cannabis and ketamine 10%

Jan M. Keppel Hesselink, David J. Kopsky

Journal:

Journal of Clinical Anesthesia

Year:

2012

Language:

english

File:

PDF, 65 KB

english, 2012

25

Letter to the Editor

Jan M. Keppel Hesselink, David J. Kopsky

Journal:

Current Therapeutic Research

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

26

A phase II multicenter dose-finding, efficacy and safety trial of ipsapirone in outpatients with generalized anxiety disorder

Cutler, Neal R., Keppel Hesselink, Jan M., Sramek, John J.

Journal:

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Year:

1994

Language:

english

File:

PDF, 1.03 MB

english, 1994

27

Neuropathic Pain as a Result of Acromegaly, Treated With Topical Baclofen Cream

Kopsky, David Jos, Keppel Hesselink, Jan M.

Journal:

Journal of Pain and Symptom Management

Year:

2013

Language:

english

File:

PDF, 40 KB

english, 2013

28

Vulvodynia and proctodynia treated with topical baclofen 5

Keppel Hesselink, Jan M., Kopsky, David J., Sajben, Nancy L.

Journal:

Archives of Gynecology and Obstetrics

Year:

2014

Language:

english

File:

PDF, 213 KB

english, 2014

29

Evolution of concepts and definitions of Parkinson's disease since 1817*

Hesselink, Jan M. Keppel

Journal:

Journal of the History of the Neurosciences

Year:

1996

Language:

english

File:

PDF, 603 KB

english, 1996

30

Behavioral pharmacology of serotonin receptor subtypes: hypotheses for clinical applications of selective serotonin ligands

Hesselink, Jan M. Keppel, Sambunaris, Angelo

Journal:

International Review of Psychiatry

Year:

1995

Language:

english

File:

PDF, 1.15 MB

english, 1995

31

Clinical Research on Acupuncture: Part 1. What Have Reviews of the Efficacy and Safety of Acupuncture Told Us So Far?

Birch, Stephen, Hesselink, Jan Keppel, Jonkman, Fokke A.M., Hekker, Thecla A.M., Bos, Aat

Journal:

Journal of Alternative and Complementary Medicine

Year:

2004

Language:

english

File:

PDF, 112 KB

english, 2004

32

Chronic idiopathic axonal neuropathy and pain, treated with the endogenous lipid mediator palmitoylethanolamide: a case collection

Keppel Hesselink, Jan

Journal:

International Medical Case Reports Journal

Year:

2013

Language:

english

File:

PDF, 414 KB

english, 2013

33

Central Neuropathic Pain in a Patient with Multiple Sclerosis Treated Successfully with Topical Amitriptyline

Kopsky, David J., Liebregts, Remko, Keppel Hesselink, Jan M.

Journal:

Case Reports in Medicine

Year:

2012

Language:

english

File:

PDF, 53 KB

english, 2012

34

Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report

Kopsky, David J., Keppel Hesselink, Jan M.

Journal:

Case Reports in Medicine

Year:

2011

Language:

english

File:

PDF, 68 KB

english, 2011

35

Serotonin and Parkinson's Disease

HESSELINK, JAN M. KEPPEL

Journal:

American Journal of Psychiatry

Year:

1993

Language:

english

File:

PDF, 231 KB

english, 1993

36

A Double-Blind, Placebo-Controlled Study Comparing the Efficacy and Safety of Ipsapirone Versus Lorazepam in Patients With Generalized Anxiety Disorder

CUTLER, NEAL R., SRAMEK, JOHN J., KEPPEL HESSELINK, JAN M., KROL, ALICE, ROESCHEN, JULIE, RICKELS, KARL, SCHWEIZER, EDWARD

Journal:

Journal of Clinical Psychopharmacology

Year:

1993

File:

PDF, 846 KB

1993

37

DOSE-FINDING STUDIES WITH IPSAPIRONE IN ANXIETY

Keppel Hesselink, Jan M., de Jongh, Perry M.C.

Journal:

Clinical Neuropharmacology

Year:

1992

File:

PDF, 533 KB

1992

38

NS1209/SPD 502, A Novel Selective AMPA Antagonist for Stroke, Neuropathic Pain or Epilepsy? Drug Development Lessons Learned

Keppel Hesselink, Jan M.

Journal:

Drug Development Research

Year:

2017

Language:

english

File:

PDF, 122 KB

english, 2017

39

Phenytoin in topical formulations augments pain reduction of other topically applied analgesics in the treatment of trigeminal neuralgia

Kopsky, David J., Keppel Hesselink, Jan M.

Journal:

Journal of Clinical Anesthesia

Year:

2017

Language:

english

File:

PDF, 185 KB

english, 2017

40

Phenytoin: a step by step insight into its multiple mechanisms of action—80 years of mechanistic studies in neuropharmacology

Keppel Hesselink, Jan M.

Journal:

Journal of Neurology

Year:

2017

Language:

english

File:

PDF, 413 KB

english, 2017

41

Fundamentals of and Critical Issues in Lipid Autacoid Medicine: A Review

Keppel Hesselink, Jan M.

Journal:

Pain and Therapy

Year:

2017

Language:

english

File:

PDF, 627 KB

english, 2017

42

Phenytoin repositioned in wound healing: clinical experience spanning 60 years

Keppel Hesselink, Jan M.

Journal:

Drug Discovery Today

Year:

2017

Language:

english

File:

PDF, 292 KB

english, 2017

43

Phenytoin: its potential as neuroprotective and retinoprotective drug

Chiosi, Flavia, Keppel Hesselink, Jan, Rinaldi, Michele, Di Staso, Silvio, Bartollino, Silvia, Costagliola, Ciro

Journal:

British Journal of Clinical Pharmacology

Year:

2017

Language:

english

File:

PDF, 118 KB

english, 2017

44

Walking with Neuropathic Pain: Paradoxical Shift from Burden to Support?

Kopsky, David J., Keppel Hesselink, Jan M., Casale, Roberto

Journal:

Case Reports in Medicine

Year:

2015

Language:

english

File:

PDF, 1.17 MB

english, 2015

45

Palmitoylethanolamide, a Natural Retinoprotectant: Its Putative Relevance for the Treatment of Glaucoma and Diabetic Retinopathy

Keppel Hesselink, Jan M., Costagliola, Ciro, Fakhry, Josiane, Kopsky, David J.

Journal:

Journal of Ophthalmology

Year:

2015

Language:

english

File:

PDF, 1.74 MB

english, 2015

46

New topical treatment of vulvodynia based on the pathogenetic role of cross talk between nociceptors, immunocompetent cells, and epithelial cells

Keppel Hesselink, Jan, Kopsky, David, Sajben, Nancy

Journal:

Journal of Pain Research

Year:

2016

Language:

english

File:

PDF, 212 KB

english, 2016

47

Skin matters! The role of keratinocytes in nociception: a rational argument for the development of topical analgesics

Keppel Hesselink, Jan, Kopsky, David, Bhaskar, Arun

Journal:

Journal of Pain Research

Year:

2016

Language:

english

File:

PDF, 143 KB

english, 2016

48

Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells

Kopsky, David, Keppel Hesselink, Jan

Journal:

Journal of Pain Research

Year:

2013

Language:

english

File:

PDF, 400 KB

english, 2013

49

Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome

Keppel Hesselink, Jan, Kopsky, David

Journal:

Journal of Pain Research

Year:

2015

Language:

english

File:

PDF, 331 KB

english, 2015

50

EMA401: an old antagonist of the AT2R for a new indication in neuropathic pain

Keppel Hesselink, Jan, Schatman, Michael E

Journal:

Journal of Pain Research

Year:

2017

Language:

english

File:

PDF, 194 KB

english, 2017